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A history of allergy to ketoprofen or ketoprofen-containing products.

Clinically significant, poorly controlled lung, stomach, liver, kidney, heart, or other vital organ disease as determined by the study doctor or nurse.

A history of, or evidence for, underlying disease in the injured area, such as osteoarthritis or gout.

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History or physical examination finding that is not compatible with safe participation in the study as determined by the study doctor, such as gastrointestinal (stomach, intestine) ulcer or bleeding within 6 months documented by an upper-gastrointestinal series (UGI x-ray, barium meal) or endoscopy (GI scope), anemia or abnormal bleeding, moderate to severe kidney disease, or moderate to severe liver disease.

Non-pharmacologic treatments of the injury other than rest, ice, compression, and/or elevation (RICE) prior to the baseline visit.

Any form of steroid use within 30 days prior to study entry.

Any form of opioid use since the time of injury.

Pharmacologic treatment (NSAIDs or analgesic medications) for the injury less than 12 hours before the baseline assessments.

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Skin lesions include open wounds, rash, papules, vesicles, and erythema associated with the site of injury.

Active skin lesions or disease at the intended site of application of the study medication.

Previous injury to the same area within 3 months prior to current injury.

Grade 3 sprain or strain, bilateral sprain or strain, or concomitant fracture or open wound at the site of the sprain or strain, or have a serious injury, as determined by the investigator (e.g., nerve damage, joint instability, or tendon rupture).

Willing to discontinue use of any pain medication or treatments not provided as part of the study.

The injury site must be accessible to the patient so that he or she can apply the study treatment himself or herself.

Have a diagnosis of uncomplicated acute soft tissue injury of the upper or lower extremity that has occurred within the 72 hours preceding the baseline visit.

Why Should I Register and Submit Results?.

The difference between what should be a $15 copay and nearly $400 non-covered price is ridiculous for a one-month supply. The one problem with compounded medicines is very few insurance companies will cover them which makes absolutely no sense since the medications being compounded are generic drugs. I get my compound lotion from a specialty pharmacy in Denver. I’m wondering if these types of medical marijuana products could also be added to the compounded lotion, mixed with the other meds. I get the pain relief without any psychological effects with either, helping me remain fully functional in my profession. This combined with CBD are a very good combination. So far I am very pleased with the results of my compound medicine as I refuse to take any opioids.

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That difference in leg length actually caused a slight scoliosis of the part of my spine with the severest arthritis, plus an anterior-rotational dislocation of the SI joint on top of the chronic back issues. In recent years the back symptoms have worsened significantly after a total knee replacement that caused a leg-length discrepancy.

I’ve been prescribed a compounded lotion for inoperable severe lumbar spine degeneration with chronic low back pain from a decades-old injury. Proposed mechanism of action and uses are also listed. Good for patients with difficulty swallowing pillsīelow is an image of various drugs that are used in compounded creams for the treatment of pain conditions.Fewer adverse effects (such as renal and gastric effects from NSAIDs).Targets numerous pain receptors at once.Delivered directly to the pain receptors.For these patients, sometimes the best solution is having a compounding pharmacy put together a number of different medications with different mechanisms of action into a compounded cream that is applied directly over the site of pain. And for some, the adverse effects and allergies of oral medications is too much to bear. Many patients need more than just one medication to treat their pain. Numerous over-the-counter products also exist. Pharmaceutical companies are getting in the game with products such as Flector patches, Voltaren gel, Pennsaid topical solution, Lidoderm patches, and Qutenza patches.

Topical administration of medications for pain management has become increasingly more common.